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4-Aminopyridine structure
Chemical Name:
4APY;4-AP;mi-w-3;AMpyra;EL 970;avitrol;vmi10-3;Neurelan;Prc 1237;VMI 10-3
Molecular Formula:
Formula Weight:
MOL File:

4-Aminopyridine Properties

Melting point:
157 °C
Boiling point:
273 °C(lit.)
refractive index 
1.5560 (estimate)
Flash point:
storage temp. 
H2O: soluble50mg/mL, clear, colorless
Crystalline Powder, Solid or Crystals
9.114(at 25℃)
White to faint grey to light yellow
Water Solubility 
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
CAS DataBase Reference
504-24-5(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H335-H401-H311-H315-H319-H370-H372-H411-H300
Precautionary statements  P260-P264-P270-P273-P280-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P307+P311-P391-P405-P501-P280h-P301+P310-P302+P352-P305+P351+P338
Hazard Codes  T+,N,T,Xi
Risk Statements  28-36/37/38-51/53-23/24/25
Safety Statements  26-36/37/39-45-60-61-37/39-28A-1
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS  US1750000
Autoignition Temperature 640 °C
Hazard Note  Toxic/Irritant
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Toxicity LD50 orally in Rabbit: 21 mg/kg
NFPA 704
3 0

4-Aminopyridine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 275875 4-Aminopyridine ≥99% 504-24-5 1g $28.2 2020-12-02 Buy
Sigma-Aldrich 1162454 Dalfampridine United States Pharmacopeia (USP) Reference Standard 504-24-5 200mg $352.8 2020-12-02 Buy
TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 25g $25 2021-06-24 Buy
TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 100g $76 2021-06-24 Buy
Alfa Aesar A12405 4-Aminopyridine, 98% 504-24-5 50g $56.7 2021-06-24 Buy

4-Aminopyridine Chemical Properties,Uses,Production


Dalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

Chemical Properties


Chemical Properties

4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

Chemical Properties

4-Aminopyridine is white to tan or brown crystalline material. Odorless.


Rush University Medical Center (United States)


Avitrol (4-aminopyridine), has repellent–toxicant properties for birds and is classed as a severe poison and irritant. This secondary bird repellent can be used as a broadcast bait, causing uncoordinated flight and distress calls and escape responses in nearby birds.




Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.


ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

brand name

Neurelan (E′lan);Ampyra.

General Description

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

Reactivity Profile

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

Health Hazard

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks

Fire Hazard

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison


UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]


Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

4-Aminopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

4-Aminopyridine Suppliers

Global( 405)Suppliers
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View Lastest Price from 4-Aminopyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-23 4-Aminopyridine
US $63.50 / KG 1KG 98% 100ton career henan chemical co

4-Aminopyridine Spectrum

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